Translating Information Into ACTION Using A Powerful Method For Self Management
Includes Technical Appendix:
• Information Theory of Aging
• Why Exercise?
• How Not To Diet
• IB Reflections
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An emerging New Paradigm: Aging and disease result from …
- Genomic instability caused by DNA damage
- Deterioration of telomeres, the protective endcaps of chromosomes
- Alterations of the epigenome that controls which genes are turned on and off
- Loss of healthy protein maintenance, known as proteostasis
- Deregulated nutrient sensing caused by metabolic changes
- Mitochondrial dysfunction
- Accumulation of senescent zombielike cells that inflame healthy cells
- Exhaustion of stem cells
- Altered intercellular communication and the production of inflammatory molecules
Nine Hallmarks of Aging in Lifespan [2019, pg 19], by David Sinclair PhD Also see Technical Appendix at end of presentation